Som beskrevet ovenfor kan person opleve medicinoverforbrugshovedpine ved anvendelse af paracetamol i længere perioder ad gangen.De aktive stoffer buprenorphin og nalbuphin er midler der virker som de andre syntetiske opioider, Males de har desuden en modsatrettet virkning, idet de også spærrer for andre opioiders virkning.Opioider anvendes hoved

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